Low Non-NMDA Receptor Current Density as Possible Protection Mechanism from Neurotoxicity of Circulating Glutamate on Subfornical Organ Neurons in Rats
The Korean Journal of Physiology and Pharmacology
;
: 177-181, 2015.
Article
in English
| WPRIM
| ID: wpr-728527
ABSTRACT
The subfornical organ (SFO) is one of circumventricular organs characterized by the lack of a normal blood brain barrier. The SFO neurons are exposed to circulating glutamate (60~100 microM), which may cause excitotoxicity in the central nervous system. However, it remains unclear how SFO neurons are protected from excitotoxicity caused by circulating glutamate. In this study, we compared the glutamate-induced whole cell currents in SFO neurons to those in hippocampal CA1 neurons using the patch clamp technique in brain slice. Glutamate (100 microM) induced an inward current in both SFO and hippocampal CA1 neurons. The density of glutamate-induced current in SFO neurons was significantly smaller than that in hippocampal CA1 neurons (0.55 vs. 2.07 pA/pF, p0.05). These results demonstrate that glutamate-mediated action through non-NMDA glutamate receptors in SFO neurons is smaller than that of hippocampal CA1 neurons, suggesting a possible protection mechanism from excitotoxicity by circulating glutamate in SFO neurons.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Subfornical Organ
/
Brain
/
Blood-Brain Barrier
/
Central Nervous System
/
N-Methylaspartate
/
Receptors, Glutamate
/
Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
/
Glutamic Acid
/
Hippocampus
/
Kainic Acid
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2015
Type:
Article
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