Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population
The Korean Journal of Physiology and Pharmacology
;
: 125-129, 2008.
Article
in English
| WPRIM
| ID: wpr-728597
ABSTRACT
The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of matrix metallopeptidase 2 (MMP2) are associated with obesity. MMP2 is an enzyme with proteolytic activity against matrix and nonmatrix proteins, particularly basement membrane constituents. To identify the relationship between polymorphisms of MMP2 and overweight/obese, we genotyped 5 SNPs (rs17242319, rs1053605, rs243849, rs2287074, and rs10775332) of the coding region of MMP2 using the Golden Gate assay on an Illumina BeadStation 500 GX. One hundred and forty two overweight/ obese (BMI > or =23) and 145 normal (BMI 18 to <23) subjects were analyzed. SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were used for the analysis of genetic data. A linkage disequilibrium (LD) block was discovered among the 5 SNPs selected, including rs17242319, rs1053605, rs243849, and rs2287074. Of the 5 polymorphisms, 2 synonymous SNPs [rs17242319 (Gly226Gly) and rs10775332 (Phe602Phe)] were found significant associations with overweight/obese. Recently, rs1132896 replaced rs17242319 as a new number (SNP database, BUILD 129). In haplotype analysis using Haploview, a haplotype (haplotype CCCA) containing a meaningful polymorphism (rs17242319) was found to be significantly different. The results suggest that MMP2 may be associated with overweight/obese in Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Basement Membrane
/
Haplotypes
/
Proteins
/
Body Mass Index
/
Linkage Disequilibrium
/
Polymorphism, Single Nucleotide
/
Clinical Coding
/
Lidocaine
/
Obesity
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2008
Type:
Article
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