Effects of Ambroxol, S-carboxymethylcysteine, Dextromethorphan and Noscapine on Mucin Release from Airway Goblet Cells
The Korean Journal of Physiology and Pharmacology
;
: 323-326, 2005.
Article
in English
| WPRIM
| ID: wpr-728713
ABSTRACT
In the present study, we investigated whether ambroxol, S-carboxymethyl-L-cysteine, dextromethorphan and noscapine affect mucin release from airway goblet cells. Confluent primary hamster tracheal surface epithelial cells were metabolically radiolabeled and chased for 30 min in the presence of varying concentrations of the above agents to assess the effects on 3H-mucin release. Noscapine stimulated mucin release during 30 min of treatment period in a dose-dependent manner. However, ambroxol, S-carboxymethyl-L-cysteine and dextromethorphan showed no significant effect on mucin release during 30 min of treatment period. We conclude that noscapine can affect mucin release by acting on airway mucin-secreting cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carbocysteine
/
Goblet Cells
/
Dextromethorphan
/
Epithelial Cells
/
Ambroxol
/
Mucins
/
Noscapine
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2005
Type:
Article
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