Renal Tubular Acidosis in Cadmium-Intoxicated Rats
The Korean Journal of Physiology and Pharmacology
;
: 41-46, 2002.
Article
in English
| WPRIM
| ID: wpr-728771
ABSTRACT
Effect of cadmium (Cd) intoxication on renal acid-base regulation was studied in adult male Sprague-Dawley rats. Cd intoxication was induced by subcutaneous injections of CdCl2 at a dose of 2 mg Cd/kg/day for 3-4 weeks. In Cd-intoxicated animals, arterial pH, PCO2 and plasma bicarbonate concentration decreased, showing a metabolic acidosis. Urine pH and urinary bicarbonate excretion increased and titratable acid excretion decreased with no change in ammonium excretion. In renal cortical brush-border membrane vesicles derived from Cd-exposed animals, the Na /H antiporter activity was significantly attenuated. These results indicate that chronic exposures to Cd impair the proximal tubular mechanism for H secretion (i.e., Na /H antiport), leading to a metabolic acidosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Acidosis
/
Acidosis, Renal Tubular
/
Cadmium
/
Rats, Sprague-Dawley
/
Ion Transport
/
Cadmium Chloride
/
Ammonium Compounds
/
Hydrogen-Ion Concentration
/
Injections, Subcutaneous
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2002
Type:
Article
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