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Ethyl Pyruvate Has Anti-Inflammatory and Delayed Myocardial Protective Effects after Regional Ischemia/Reperfusion Injury
Yonsei Medical Journal ; : 838-844, 2010.
Article in English | WPRIM | ID: wpr-72898
ABSTRACT

PURPOSE:

Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue injury. The aim of this study was to determine whether ethyl pyruvate decreases the inflammatory response after regional I/R injury and whether ethyl pyruvate protects against delayed regional I/R injury in an in vivo rat heart model after a 24 hours reperfusion. MATERIALS AND

METHODS:

Rats were randomized to receive lactated Ringer's solution or ethyl pyruvate dissolved in Ringer's solution, which was given by intraperitoneal injection 1 hour prior to ischemia. Rats were subjected to 30 min of ischemia followed by reperfusion of the left coronary artery territory. After a 2 hours reperfusion, nuclear factor kappaB, myocardial myeloperoxidase activity, and inflammatory cytokine levels were determined. After the 24 hours reperfusion, the hemodynamic function and myocardial infarct size were evaluated.

RESULTS:

At 2 hours after I/R injury, ethyl pyruvate attenuated I/R-induced nuclear factor kappaB translocation and reduced myeloperoxidase activity in myocardium. The plasma circulating levels of inflammatory cytokines decreased significantly in the ethyl pyruvate-treated group. At 24 hours after I/R injury, ethyl pyruvate significantly improved cardiac function and reduced infarct size after regional I/R injury.

CONCLUSION:

Ethyl pyruvate has the ability to inhibit neutrophil activation, inflammatory cytokine release, and nuclear factor kappaB translocation. Ethyl pyruvate is associated with a delayed myocardial protective effect after regional I/R injury in an in vivo rat heart model.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyruvates / Reperfusion Injury / Cell Nucleus / NF-kappa B / Rats, Sprague-Dawley / Peroxidase / Cytoplasm / Heart / Inflammation / Anti-Inflammatory Agents Type of study: Prognostic study Limits: Animals Language: English Journal: Yonsei Medical Journal Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyruvates / Reperfusion Injury / Cell Nucleus / NF-kappa B / Rats, Sprague-Dawley / Peroxidase / Cytoplasm / Heart / Inflammation / Anti-Inflammatory Agents Type of study: Prognostic study Limits: Animals Language: English Journal: Yonsei Medical Journal Year: 2010 Type: Article