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Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius
Mycobiology ; : 117-120, 2016.
Article in English | WPRIM | ID: wpr-729443
ABSTRACT
During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance (¹H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC₅₀ values in the range of 0.7~8.1 µM.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Orthomyxoviridae / Protons / Magnetic Resonance Spectroscopy / Chromatography / Methanol / Fruit / Fungi / Neuraminidase Language: English Journal: Mycobiology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Orthomyxoviridae / Protons / Magnetic Resonance Spectroscopy / Chromatography / Methanol / Fruit / Fungi / Neuraminidase Language: English Journal: Mycobiology Year: 2016 Type: Article