The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage

Wol-Soon JO; Yoo-Jin CHOI; Hyoun-Ji KIM; Jae-Yun LEE; Byung-Hyouk NAM; Jae-Dong LEE; Sang-Wha LEE; Su-Yeong SEO; Min-Ho JEONG

Wol-Soon JO; Yoo-Jin CHOI; Hyoun-Ji KIM; Jae-Yun LEE; Byung-Hyouk NAM; Jae-Dong LEE; Sang-Wha LEE; Su-Yeong SEO; Min-Ho JEONG.

Mycobiology ; : 46-51, 2010.

Article in English | WPRIM | ID: wpr-729549

ABSTRACT

ABSTRACT

The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-alpha and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.

Subject(s)

Cordyceps; Fruit; Interleukin-6; Macrophages; Nitric Oxide; Tumor Necrosis Factor-alpha; Water

Anti-inflammatory activity; Cordyceps militaris; Lipopolysaccharide; Nitric oxide; Pro-inflammatory cytokines; RAW 264.7 cell

Fulltext

XML

Search on Google

Full text: Available Index: WPRIM (Western Pacific) Main subject: Water / Interleukin-6 / Tumor Necrosis Factor-alpha / Cordyceps / Fruit / Macrophages / Nitric Oxide Language: English Journal: Mycobiology Year: 2010 Type: Article

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

Search on Google