Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus
Mycobiology
;
: 142-144, 2012.
Article
in English
| WPRIM
| ID: wpr-729678
ABSTRACT
During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to 1H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC50 values of 13.1 and 0.03 microM, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyrones
/
Retention, Psychology
/
Chromatography
/
Chromatography, High Pressure Liquid
/
Chromatography, Liquid
/
Dextrans
/
Inhibitory Concentration 50
/
Fungi
/
Neuraminidase
Language:
English
Journal:
Mycobiology
Year:
2012
Type:
Article
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