LAMMER Kinase Lkh1 Is an Upstream Regulator of Prk1-Mediated Non-Sexual Flocculation in Fission Yeast
Mycobiology
;
: 236-241, 2018.
Article
in English
| WPRIM
| ID: wpr-729775
ABSTRACT
The cation-dependent galactose-specific flocculation activity of the Schizosaccharomyces pombe null mutant of lkh1⁺, the gene encoding LAMMER kinase homolog, has previously been reported by our group. Here, we show that disruption of prk1⁺, another flocculation associated regulatory kinase encoding gene, also resulted in cation-dependent galactose-specific flocculation. Deletion of prk1 increased the flocculation phenotype of the lkh1⁺ null mutant and its overexpression reversed the flocculation of cells caused by lkh1 deletion. Transcript levels of prk1⁺ were also decreased by lkh1⁺ deletion. Cumulatively, these results indicate that Lkh1 is one of the negative regulators acting upstream of Prk1, regulating non-sexual flocculation in fission yeast.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Phosphotransferases
/
Schizosaccharomyces
/
Flocculation
Language:
English
Journal:
Mycobiology
Year:
2018
Type:
Article
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