Inherited thrombophilia profile in patients with recurrent miscarriages: Experience from a tertiary care center in north India
Obstetrics & Gynecology Science
;
: 514-517, 2015.
Article
in English
| WPRIM
| ID: wpr-72979
ABSTRACT
The cause of recurrent miscarriage (RM) remains unexplained in approximately 30% to 50% cases. The association of inherited thrombotic factors and RM patients has not been documented from the northern part of India. A total of 40 patients had been investigated for inherited thrombophilia workup (protein C, protein S [PS], antithrombin III, and factor V Leiden [FVL] mutation) over a period of 10 years (2005 to 2014). RM patients were divided in to three groups. Group I (only 1st trimester loss), group II (only 2nd and 3rd trimester), and group III (mixed). Each group comprised of the following numbers of patients respectively I, 24; II, 2; III, 14. Heterozygous FVL mutation was found in 10% (4/40) cases. PS deficiency was detected in 2.7% (1/37) cases. In the present study FVL and PS were seems to be associated with a subset of patients however further studies with larger numbers of patients are recommended for better evaluation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tertiary Healthcare
/
Factor V
/
Antithrombin III
/
Abortion, Habitual
/
Protein S
/
Thrombophilia
/
Tertiary Care Centers
/
India
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
Language:
English
Journal:
Obstetrics & Gynecology Science
Year:
2015
Type:
Article
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