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Endovascular Embolization of Intracranial Aneurysms Using Bare Platinum Axium(TM) Detachable Coils: Immediate and Short-Term Follow-up Results from a Multicenter Registry / 신경중재치료의학
Neurointervention ; : 85-92, 2012.
Article in English | WPRIM | ID: wpr-730232
ABSTRACT

PURPOSE:

Axium(TM) coils were developed to improve the durability of coil-embolized cerebral aneurysms by increasing packing density. The purpose of this prospective multicenter registry was to evaluate the safety and durability of Axium(TM) coils. MATERIALS AND

METHODS:

One hundred twenty-six patients with 135 aneurysms of < or = 15 mm in size underwent coil embolization using bare platinum coils, with Axium(TM) coils constituting over 50% of the total coil length. Immediate and short-term follow-up results were prospectively registered and retrospectively evaluated.

RESULTS:

Of the 135 aneurysms (83 unruptured and 52 ruptured), immediate post-embolization angiography revealed complete occlusion in 80 aneurysms (59.3%), neck remnants in 47 (34.8%), and incomplete occlusion in 8 (5.9%). The mean packing density was 42.8% (range, 9.5 - 90%) with Axium(TM) coil length constituting a mean of 87.9% of total coil length. The rate of procedure-related complications was 16.3%. Procedure-related permanent morbidity and mortality rates were 3.2% and 0.8%, respectively. Follow-up catheter or MR angiography, which was available in 101 aneurysms at 6 - 15 months (mean, 7.7 months), revealed stable or improved occlusion in 95 aneurysms and worsening in 6 aneurysms (5.9%). Lower packing density (< 30%) remained the only predictor for anatomical worsening on multivariable logistic regression analysis (P < 0.05).

CONCLUSION:

In this registry, Axium(TM) coils showed a relatively low rate of anatomical worsening on short-term follow-up imaging with an acceptable periprocedural safety profile compared to reports of other platinum coils. These results may warrant further study of long-term durability with Axium(TM) coils in larger populations.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Platinum / Angiography / Logistic Models / Intracranial Aneurysm / Prospective Studies / Retrospective Studies / Follow-Up Studies / Catheters / Aneurysm / Neck Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Neurointervention Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Platinum / Angiography / Logistic Models / Intracranial Aneurysm / Prospective Studies / Retrospective Studies / Follow-Up Studies / Catheters / Aneurysm / Neck Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Neurointervention Year: 2012 Type: Article