Acetazolamide-Challenged Brain CT Perfusion before and after Carotid Stenting / 신경중재치료의학
Neurointervention
;
: 107-115, 2009.
Article
in English
| WPRIM
| ID: wpr-730347
ABSTRACT
PURPOSE:
To test hypothesis that pre-stenting measurement of reactivity index by using acetazolamide-challenged CT perfusion could identify patients at risk for hyperperfusion after carotid stenting. MATERIALS ANDMETHODS:
For 24 regions of interest in 12 patients with symptomatic unilateral high-grade carotid stenosis, asymmetric indexes for cerebral blood volume, cerebral blood flow, and mean transit time and reactivity index were calculated from resting and acetazolamide-challenged CT perfusion before and 1 day after carotid stenting. We subsequently compared pre-stenting asymmetric indexes and reactivity index with percent increase of cerebral blood flow 1 day after carotid stenting.RESULTS:
Percent increase of cerebral blood flow on the first post-stenting day was not significantly different between visually decreased and normal cerebrovascular reserve groups. There was no significant correlation between pre-stenting asymmetric indexs of resting CT perfusion parameters and percent increase of cerebral blood flow 1 day after carotid stenting. On the other hand, pre-stenting reduction of reactivity index showed fair correlation with 1 day cerebral blood flow increase. However, hyperperfusion or hyperperfusion syndrome was not observed in any patient with reduced reactivity index.CONCLUSION:
Pre-stenting measurements of resting CT perfusion parameters and reactivity index could not predict hyperperfusion after carotid stenting. However, pre-stenting reduction of reactivity index seems to fairly correlate with immediate post-stenting cerebral blood flow increase. Further studies with larger population should be performed to validate this preliminary result.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Blood Volume
/
Brain
/
Stents
/
Carotid Stenosis
/
Hand
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Neurointervention
Year:
2009
Type:
Article
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