A Case of P-ANCA Positive Necrotizing Glomerulonephritis with Eosinophilia / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 83-89, 2000.
Article
in Korean
| WPRIM
| ID: wpr-73088
ABSTRACT
Antineutrophil cytoplasmic antibodies (ANCAs) are now regarded as a serologic marker for pauci-immune crescentic necrotizing glomerulonephritis either in renal-limited form or in association with systemic vasculitis, such as Wegener? granulomatosis, microscopic polyarteritis, and Churg-Strauss syndrome. Two major ANCA antigens have been indentified proteinase3, which produces a cytoplasmic staining pattern termed C-ANCA, and myeloperoxidase, which produces a perinuclear pattern termed P-ANCA on ethanol-fixed neutrophils by indirect immunofluorescence. In ANCA- associated diseases, eosinphilia in excess of 1.5X109/L has been proposed to be characteristic of Churg-Strauss syndrome and is rare in other forms of ANCA-associated systemic vasculitis and crescentic necrotizing glomerulonephritis. Recently, there were two cases of P-ANCA positive crescentic necrotizing glomerulonephritis with peripheral blood eosinophilia and extrarenal microscopic vasculitis without asthma or granulomas. We experienced a patient with P-ANCA positive pauci-immune necrotizing glomerulonephritis with few eosinophilic infiltration and eosinophilia. He improved with oral prednisolone along with combination of intravenous cyclophosphamide. So we report this case with the review of literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Vasculitis
/
Prednisolone
/
Churg-Strauss Syndrome
/
Peroxidase
/
Fluorescent Antibody Technique, Indirect
/
Antibodies, Antineutrophil Cytoplasmic
/
Cyclophosphamide
/
Cytoplasm
/
Eosinophilia
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS