Ultrasound contrast-enhanced study as an imaging biomarker for anti-cancer drug treatment: preliminary study with paclitaxel in a xenograft mouse tumor model (secondary publication)
Ultrasonography
;
: 370-377, 2017.
Article
in English
| WPRIM
| ID: wpr-731012
ABSTRACT
PURPOSE:
The purpose of this study was to assess tumor angiogenesis using contrast-enhanced ultrasonography (CEUS) of human prostate cancer cells (PC3) that were implanted in mice before and after paclitaxel injection.METHODS:
Twelve mice were injected with human PC3. The mice were grouped into two groups; one was the paclitaxel-treated group (n=6) and the other was the control group (n=6). Before administering paclitaxel into the peritoneal cavity, baseline CEUS was performed after the administration of 500 μL (1×108 microbubbles) of contrast agent. The area under the curve (AUC) up to 50 seconds after injection was derived from the time-intensity curves. After injection of paclitaxel or saline, CEUS studies were performed at the 1-week follow-up. Changes in tumor volume and the AUC in both two groups were evaluated. After CEUS, the microvessel density (MVD) was compared between the groups.RESULTS:
In the paclitaxel-treated group, the AUC from CEUS showed a significant decrease 1-week after paclitaxel administration (P=0.030), even though the tumor volume showed no significant changes (P=0.116). In the control group, there was no significant decrease of the AUC (P=0.173). Pathologically, there was a significant difference in MVD between both groups (P=0.002).CONCLUSION:
The AUC from the time intensity curve derived from CEUS showed an early change in response to the anti-cancer drug treatment that preceded the change in tumor size. The findings of CEUS could serve as an imaging biomarker for assessing tumor responses to anti-cancer drug treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peritoneal Cavity
/
Prostatic Neoplasms
/
Follow-Up Studies
/
Ultrasonography
/
Paclitaxel
/
Area Under Curve
/
Tumor Burden
/
Microvessels
/
Heterografts
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Ultrasonography
Year:
2017
Type:
Article
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