Effects of Conbercept combined with laser on inflammatory factors, oxidative stress levels and retinal hemodynamics in diabetic retinopathy / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM:To explore the effects of Conbercept combined with laser on inflammatory factors, oxidative stress levels and retinal hemodynamics in diabetic retinopathy. <p>METHODS: One hundred patients with diabetic retinopathy who were diagnosed and treated in our hospital from October 2015 to February 2017 were randomly divided into control group and observation group, 50 cases in each group. The control group was given laser treatment. The observation group was treated with conbercept on the basis of the control group. Afterwards, the clinical efficacy, inflammatory factors, oxidative stress and retinal hemodynamic level were tested before and after treatment of two groups of patients. <p>RESULTS: There was no significant difference in LogMAR value and retinal thickness between the two groups before treatment(<i>P</i>>0.05). After treatment, both LogMAR values of visual acuity and retinal thickness decreased significantly in the two groups. After treatment, the LogMAR value of visual acuity of the observation group was 0.65±0.05, the thickness of retina was 157.97±15.51μm, which was significantly lower than that of the control group(<i>P</i><0.05). After treatment, the levels of IL-1β, IL-6 and IL-8 in serum were significantly lower than those before treatment. The levels of IL-1β, IL-6 and IL-8 of the observation group were 16.93±0.48ng/L, 92.22±1.03pg/mL and 0.33±0.06ng/L respectively, which were significantly lower than those of the control group after treatment(<i>P</i><0.05). The levels of MDA, LHP and ROS in the two groups significantly decreased after treatment, and the levels of MDA, LHP and ROS in the observation group were 4.16±0.21μmol/L, 164.97±6.51μmol/L and 261.15±14.44μmol/L, which was significantly lower than that of the control group after treatment(<i>P</i><0.05). After treatment, PSV and EDV levels in both groups significantly increased, and RI levels significantly decreased. The levels of PSV and EDV in the observation group were 9.59±0.22cm/s and 2.96±0.05cm/s, respectively, which were significantly higher than those in the control group. The RI level in the control group was 0.66±0.04, which was significantly lower than that in the control group(<i>P</i><0.05). <p>CONCLUSION: Conbercept combined with laser can effectively improve the vision of patients with retinopathy, reduce retinal thickness, reduce the levels of inflammatory cytokines and oxidative stress, and improve retinal hemodynamics. The curative effect is reliable.