Association of interleukin-6 gene -572C/G polymorphisms with type 2 diabetic retinopathy / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM: To investigate the relationship of IL-6 gene -572C/G polymorphism in patients with type 2 diabetic retinopathy(T2DM)and diabetic retinopathy(DR)in Dali Bai population.<p>METHODS: The polymorphisms of IL-6 gene -572C/G was analyzed by polymerase chain reaction-restriction fragment polymorphisms assay(PCR-RFLP)in 150 patients with T2DM \〖NDR(without DR)group 57 cases, NPDR(with non-proliferative diabetic retinopathy)group 77 cases, PDR(with proliferative diabetic retinopathy)group 16 cases\〗 and 100 healthy control group in Dali Bai population. The genotypes frequency, allele frequency of IL-6-572C/G gene and clinical data were compared between groups. The statistics software SPASS22.0 was used for statistical analysis.<p>RESULTS: The genotype and allele frequencies of IL-6 gene -572C/G between groups were compared statistically significantly(<i>P</i><0.05); the incidence of T2DM in healthy control subjects with C allele significantly decreased in comparison with the carriers of G allele(<i>OR</i>=1.182, <i>95% CI</i> 1.059-1.319, <i>P</i>=0.004); the incidence of DR in T2DM with G allele significantly increased in comparison with the carriers of C allele(<i>OR</i>=1.667, 95% <i>CI</i> 1.195-2.326, <i>P</i>=0.003), but there was no statistical difference between PDR group with NPDR group for -572C/G polymorphism(<i>P</i>>0.05). There was statistical significant between T2DM group, NPDR + PDR and control groups in fasting blood glucose, triglycerides, body mass index(<i>P</i><0.05), PDR group was compared with NPDR group only in difference between fasting plasma glucose(<i>P</i><0.05). The hypertension in individuals suffering from T2DM increased in comparison with not combing hypertension(<i>OR</i>=3.730, 95% <i>CI</i> 2.060-6.754, <i>P</i>=0.000), and suffering from DR increased obviously(<i>OR</i>=3.997, 95%<i>CI</i>2.099-7.612, <i>P</i>=0.000). The clinical data showed no significant difference(<i>P</i>>0.05)among different genotypes.<p>CONCLUSION: These results suggest that the -572C/G polymorphism in the promoter of IL-6 gene is associated with T2DM and DR in Dali Bai population, but the clinical data is not coordinative risk factor. G allele is a risk factor in the pathogenesis of T2DM and DR, but not for the progress in NPDR to PDR process, C alleles is a protective factor T2DM and DR. Hypertension, fasting blood glucose, triglycerides, body mass index were risk factors for T2DM and DR, fasting blood glucose condition in DR progress has an important role.