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Detecting the Expression of ST3GalⅤ in Human Hepatic Carcinoma Cell Lines by Sialyltransferase DNA Microarray / 沈阳医学院学报
Journal of Shenyang Medical College ; (6): 142-145, 2016.
Article in Chinese | WPRIM | ID: wpr-731750
ABSTRACT

Objective:

To investigate the differential expression of ST3GalⅤ in human hepatic carcinoma cell lines, HepG?2 and SMMC?7721 and normal hepatic cell line, L?02 by sialyltransferase DNA microarray.

Methods:

Expression of ST3Gal family was measured with DNA microarray. Western blot was used to verify DNA microarrays data.

Result:

ST3GalⅤ downregulated in HepG?2 and SMMC?7721 cell lines, compared with control cell line.

Conclusion:

The downregulation of ST3GalⅤ in HepG?2 and SMMC?7721 cell lines may result in the reduction of GD1a and influence the hepatocyte proliferations.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Shenyang Medical College Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Shenyang Medical College Year: 2016 Type: Article