Effects of Spironolactone Combining Chinese Medical Herbs on the Treatment of Patients with Stage ШDiabetic Nephropathy / 沈阳医学院学报

ABSTRACT

Objective:To explore the effect of spironolactone combining Chinese medical herbs on the treatment of patients with diabetic nephropathy. Methods:Diabetes patients with stage III diabetic nephropathy were randomized into 2 group (24 cases in each group) . A group was treated with spironolactone, while B group were treated with spironolactone combining Chinese medical herbs both for 2 months. Urinary albumin excretion rate (UAER) and creatinine (Scr) were tested on ex-treatment,at the end of treatment,and the thirth,sixth,12th month after treatment. Results:UAER and Scr of A,B group at the end of treatment,the thirth month after treatment were lower significantly than ex-treatment. UAER and Scr in B group on the point in time the sixth,12th month after treatment were lower significantly than ex-treatment. At the end of treatment, and thirth, sixth, 12th month after treatment, UAER and Scr in B group were lower than those in A group. Conclusion:The long-range effect of spironolactone combining Chinese medical herbs are better than single spironolactone on the patients with stageШdiabetic nephropathy.