Progress in animal models of age-related macular degeneration / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#Age related macular degeneration(ARMD)is the leading cause of blindness in people over 65 years of age. The need for research on effective treatments of ARMD has led to the development of multiple animal models. ARMD is a complex process involving interaction of age, genetic and environmental factors. Animal models have reconstructed many of the histological features in ARMD, making it possible to better understand the underlying pathogenesis of the disease. Although no model can replicate all the phenotypes of human ARMD, it can express different characteristics of ARMD, revealing the roles of chronic oxidative damage, inflammation, immune dysregulation and lipid metabolism in the development of ARMD. This article will review the various ARMD animal models that have been reported. By analyzing the advantages and limitations of each model, it will provide some help for the selection of appropriate animal models for ARMD research and provide new modeling ideas.