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Autologous mononuclear cells from different sources are seen to improve wound healing in patients with haematological malignancies
The Malaysian Journal of Pathology ; : 61-67, 2018.
Article in English | WPRIM | ID: wpr-732419
ABSTRACT

Introduction:

Immunosuppressive state due to haematological malignancies and chemotherapy may cause disruption to wound healing despite optimum conventional treatment and standard wound dressing. Non-healing wounds are predisposed to infection whereas chemotherapy dose reductions or interruptions are associated with poor survival.

Background:

Mononuclear cells contain progenitor cells including haematopoietic and mesenchymal stem cells, endothelial progenitor cells and fibroblasts which facilitate wound healing through cytokines, growth factor secretions, cell-cell interactions and provision of extracellular matrix scaffolding. Clinical applications of autologous mononuclear cells therapy in wound healing in non-malignant patients with critical limb ischaemia have been reported with remarkable outcome.

Methods:

We report three patients with haematological malignancies undergoing chemotherapy, who received autologous mononuclear cells implantation to treat non-healing wound after optimum conventional wound care. The sources of mononuclear cells (MNC) were from bone marrow (BM), peripheral blood (PB) and mobilised PB cells (mPB-MNC) using granulocyte colony stimulating factor (G-CSF). The cells were directly implanted into wound and below epidermis. Wound sizes and adverse effects from implantation were assessed at regular intervals.

Results:

All patients achieved wound healing within three months following autologous mononuclear cells implantation. No implantation adverse effects were observed.

Conclusions:

Autologous mononuclear cells therapy is a feasible alternative to conventional wound care to promote complete healing in non-healing wounds compounded by morbid factors such as haematological malignancies, chemotherapy, diabetes mellitus (DM), infections and prolonged immobility.

Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: The Malaysian Journal of Pathology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: The Malaysian Journal of Pathology Year: 2018 Type: Article