Progress of hematopoietic microenvironment / 白血病·淋巴瘤

ABSTRACT

The hematopoietic microenvironment provides an important place for hematopoietic stem cell (HSC) to self-renew, directional differentiation and maintain relative homeostasis, and it can regulate hematopoietic activity through various cellular components and factors. HSC is a primitive pluripotent stem cell in the blood system featured by the potential ability to self-renew for a long time and to differentiate into various mature blood cells, which exists in the bone marrow (BM). HSC plays an important role in regulating and maintaining the physiological balance of various cellular components of the blood system in the body, to ensure the continuous regeneration of the blood system. The hematopoietic microenvironment affects the development of HSC all the time, but the related cellular molecules and signals in the microenvironment still need to be studied in depth. This paper reviews the main components of the hematopoietic microenvironment, signaling pathways and the effects of abnormal changes on the diseases.