Research progress of miR-224 in colorectal cancer / 国际外科学杂志

ABSTRACT

Colorectal cancer is the third most common cancer in humans and poses a serious threat to human health.MicroRNAs (miRNAs) affected the mechanism of occurrence and development of colorectal cancer.As an important member of miRNA,miR-224 modulates the migration,proliferation,metastases and drug resistance of colorectal cancer by acting on its downstream targets.The expression of miR-224 affects the prognosis of colorectal cancer.Therefore,this review summarizes the role of miR-224 and its downstream targets in colorectal cancer,it may provide a new method for diagnosis and treatment to colorectal cancer at the cellular and molecular level.