Study on cell matrix of pancreatic duct adenocarcinoma / 国际肿瘤学杂志

ABSTRACT

The occurrence of pancreatic duct adenocarcinoma (PDAC) is closely related to the biological immunological characteristics of the hematopoietic matrix of its cancer cells.The malignant characteristics of the cancer matrix play important roles in the malignant origin of tumors,avoiding immune surveillance,promoting tumor progression and growth,and increasing drug resistance and metastasis.Understanding the important roles of hyaluronic acid,Sonic Hedgehog signaling pathway,transforming growth factor-beta,CD40,Kras pathway and microRNA in the pathogenesis and development of PDAC,can provide new strategies for clinical treatment of PDAC.