Mycoplasma pneumoniae pneumonia complicated with Legioneila pneumophila infection in 29 children / 中华实用儿科临床杂志

ABSTRACT

Objective To summarize the clinical features of mycoplasma pneumoniae pneumonia(MPP) complicated with legionella pneumophila(LP) infection in children.Methods Sixty-two cases of MPP were admitted in the Department of Pediatrics,the Sixth People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University from Aug.2011 to Feb.2012 were enrolled.Serum antibodies of MP(IgM,IgG) were determined by passive agglutination method and serum antibody(IgM) of LP serogroup-1 was detected by indirect immunofluorescence method.The patients were divided into 2 groups(29 patients in MPP group complicated with LP infection and 33 patients in MPP group).Gender,age,clinical symptoms,duration of hospitalization,extra pulmonary complications and chest iconography were compared between the 2 groups.The SAS 6.12 software was used to analyze the data.Results Of the children in MPP complicated with LP infection group and MPP group,29 cases and 33 cases(100.0％,100.0％) had cough and fever,23 cases and 21 cases(79.3％,63.6％) had pulmonary crackles and(or) wheezing,6 cases and 12 cases(20.7％,36.4％) had no pulmonary signs,21 cases and 16 cases (72.4％,48.5％)had extra pulmonary complications.Chest X-ray (or/and chest CT)revealed bronchopneumonia in 18 cases and 22 cases (62.1％,66.7％),lobar pneumonia in 8 cases and 8 cases (27.6％,24.2％),interstitial pneumonia in 0 case and 2 cases (0.0,6.1％),atelectasis in 2 cases and 0 case(6.9％,0.0),and pleural effusion in 1 case and 1 case(3.4％,3.0％).Compared with MPP group,the significant differences were found in febrile days,cough days,pulmonary rales duration and length of stay in MPP with LP infection group(all P ＜ 0.05).The number of elevated CRP cases and granulocytopenia in the MPP group with LP was higher than that in the MPP group(P ＜ 0.05).But no significant difference was found in gender,age,the cases of pulmonary rales or the chest iconography type(all P ＞ 0.05).Conclusions Compared with MPP children,MPP with LP children had longer febrile and cough days,severe pulmonary rales and duration of hospitalization.The clinical symptoms and signs were much severe in MPP patients with LP infection patients.