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Observation of ultrastructure of morphological relationship between neurons and astrocytes in hippocampi of pentylenetetrazol-kindled epileptic rats / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics ; (24): 373-376, 2013.
Article in Chinese | WPRIM | ID: wpr-732975
ABSTRACT
Objective To observe ultrastructure of the morphological relationship between neuron and astrocytes in hippocampi of pentylenetetrazol (PTZ)-kindled epileptic rats,and to investigate the communicative ways between them.Methods Epilepsy models of 10 kindled rats established by intraperitoneal injection of PTZ[i.p.,35 mg/(kg · d)],assigned as kindled group.Five rats received 9 g/L saline as control group.Three days after being kindled,the ultrastructural relationship between neurons and the astrocytes was observed with transmission electron microscope and Cx43 labelling immuno-electron microscopy.Results 1.Synapses increased in hippocampi of PTZ-kindled epileptic rats.2.Gap junctions were observed between astrocytes and neurons.3.Astrocytic process extended into the synaptic cleft between pre-synaptic and post-synaptic membranes which formed the synaptic complex.4.The Cx43-hemichannels existed between astrocytes and neurons.Conclusions In hippocampi of PTZ-kindled epileptic rats,ultrastructure of morphological relationship between neurons and astrocytes includes synaptic complex,gap junctions and hemichannels,which might be communicative forms between neurons and astrocytes.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Applied Clinical Pediatrics Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Applied Clinical Pediatrics Year: 2013 Type: Article