Observation of high dose prednisone oral treatment in children with immune thrombocytopenia / 中华实用儿科临床杂志

ABSTRACT

Objective To explore curative effects of high-dose prednisone used for children with immune thrombocytopenia (ITP).Methods The children with ITP were divided into prednisone group,γ-globulin group and methylprednisolone group.Platelet levels in peripheral blood were recorded after treatments within the 5th day and the 30th day,and the blood pressure levels of children were also recorded during treatments.Thex2 test was used to compare the effective rate of different treatments as well as the incidence rate of hypertension in these 3 groups.Results In new diagnosis children,there was no significant difference in the effective rate among the 3 groups in the 5th day(P ＞ 0.05).The effective rate of prednisone group in the 30th day was significantly higher than γ-globulin group (P ＜0.05),and there was no significant difference than methylprednisolone group (P ＞ 0.05).In persistence and chronic ITP children,the effective rate of prednisone group were both significantly higher than those in γ-globulin group in the 5th days and the 30th day (P ＜0.05),and were also no significantly higher than those in methylprednisolone group (P ＞ 0.05).The incidence rate of hypertension was significantly lower in prednisone group than that in methylprednisolone group (P ＜ 0.05).Conclusion High-dose prednisone oral treatment is safe,effective and worth using in children with ITP.