Clinical Relevance of Elevated Levels of Serum Soluble Interleukin-2 Receptor alpha (sIL-2Ralpha) in Patients with Non-Hodgkin's Lymphoma / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 600-605, 2010.
Article
in English
| WPRIM
| ID: wpr-73310
ABSTRACT
Levels of soluble interleukin-2 receptor alpha (sIL-2Ralpha) are known to increase in the sera of patients with certain malignancies, including malignant lymphoma. This study aimed to assess the clinical significance of the sIL-2Ralpha level in non-Hodgkin's lymphoma (NHL). We used ELISA to measure the sIL-2Ralpha levels in 48 newly diagnosed and untreated patients with NHL and evaluated the correlation between the sIL-2Ralpha levels and clinical characteristics and the International Prognostic Index (IPI). We monitored serum sIL-2Ralpha in 7 patients to compare the changes in their clinical progress with these levels. High levels of serum sIL-2Ralpha (> or =2,000 U/mL) correlated well with parameters defining the high risk group according to the IPI, i.e., high tumor burden at diagnosis (stage III+IV) and lactate dehydrogenase > or =472 U/L. The levels were also associated with B symptoms, bone marrow involvement, and poor response to therapy. The sIL-2Ralpha level decreased during complete remission and was elevated during disease progression or relapse. A high level of sIL-2Ralpha was significantly associated with a low survival rate. These results suggest that serum sIL-2Ralpha might be useful as a biomarker for evaluating the prognosis of patients with NHL at the time of diagnosis and during therapy. A well-controlled, large-scale study is needed to clarify the clinical significance of sIL-2Ralpha in specific groups of NHL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Lymphoma, Non-Hodgkin
/
Biomarkers
/
Survival Rate
/
Interleukin-2 Receptor alpha Subunit
/
L-Lactate Dehydrogenase
/
Neoplasm Staging
Type of study:
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Laboratory Medicine
Year:
2010
Type:
Article
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