Risk factors of bronchopulmonary dysplasia in preterm infants and predictive value of Score for Neonatal Acute Physiology on incidence of bronchopulmonary dysplasia / 中华实用儿科临床杂志

ABSTRACT

Objective To investigate the risk factors of bronchopulmonary dysplasia (BPD) in preterm infants,and to explore the clinical application value of Score for Neonatal Acute Physiology(SNAP) in predicting the development of BPD.Methods The clinical and laboratory data of 202 premature infants with gestational age ＜ 35 weeks were reviewed.The premature infants were divided into BPD group and non-BPD group,the SNAP values for each infant during the first 24 hours of admission were calculated,the risk factors of BPD were analyzed,and the relationship between SNAP and the development of BPD was analyzed.Results There were significant differences in gestational age,birth weight and 5 min Apgar score,serum albumin between BPD group and non-BPD group(all P ＜0.05).The incidences of respiratory distress syndrome,apnea of prematurity,respiratory failure,hospital-acquired infection,anemia,patent ductus arteriosus,brain damage in BPD group were significantly higher than those in non-BPD group (all P ＜0.05).In addition,compared with non-BPD group,the times and duration of mechanical ventilation and oxygen therapy were longer in BPD group(all P ＜ 0.05).Multivariate Logistic regression revealed that gestational age,SNAP,hospitalacquired infection,and apnea of prematurity were independent risk factors of BPD (all P ＜ 0.05).The sensitivity of the SNAP was 88.6％ in predicting the development of BPD.Conclusions The development of BPD in premature infants is related with multiple factors,which provide useful information for further research on BPD.In addition,the SNAP values in premature infants can be used to predict the development of BPD.