Clinical examination comparison of under 2 years old patients with and without vesicoureteral reflux / 中华实用儿科临床杂志

ABSTRACT

Objective To provide some evidence for choosing the strategy for conducting micturating cystourethrography(MCU) examination in infants under 2 years old with urinary tract infection(UTI) by comparing the clinical examinations in patients under 2 years old with and without vesicoureteral reflux.Methods One hundred and twelve inpatients from Yuying Children's Hospital,Wenzhou Medical University,under 2 years old with UTI from Jan.2009 to Dec.2011 were collected,The incidence of vesicoureteral reflux(VUR) among 3 groups(＜ 6 months old,6 months to 1 year old and 1 to 2 years old) was analyzed and the differences in body temperature,white blood cell,C-reacting protein (CRP),urinary β2-microglobulin (β2-MG),urine N-acety1 glucosaminidase (NAG),ultrasound examination (USG)anomaly and dimercaptosuccinic acid (DMSA) anomaly between VUR positive and negative patients were compared.Results The detection rate of VUR and the grade of regurgitation were not statistically different in each age group of infants under 2 years old with UTI.There were 10 cases with urine β2-MG increasing in VUR positive group,significantly higher than those in the VUR negative group(6 cases) (P ＜0.01),but there was no difference in others.Conclusions The urine β2-MG increasing is the intense indication for performing MCU in infant under 2 years old with UTI,and the possibility of VUR in these patients even without fever should also be vigilant.