Effect of glutamine on gastrointestinal function in full-term newborn infants with asphyxia / 中华实用儿科临床杂志

ABSTRACT

Objective To explore the changes of bowel functions in mild asphyxial full-term neonates and evaluate the possible effect of glutamine (Gln) on intestinal barrier function.Methods A prospective,blind,randomized controlled clinical study was conducted in neonatal ward and maternity ward of the Affiliated Hospital of Guangdong Medical College.Thirty-seven mild asphyxial neonates and 15 normal neonates were included.The 37 asphyxiated term infants were randomly divided into 2 groupsasphyxia group and asphyxia control group.The 20 infants in the asphyxia group were given Gln [0.3 g/(kg · d)] based on supporting treatment,added in breast milk or formula,3 times in daily.The 17 infants in asphyxia control group were fed with equal amount of 9 g/L saline supplementation.The same term 15 normal neonates as healthy control group were breast fed in obstetrics.The intervention lasted 1 week.Blood samples were collected from the 3 groups on day 1,3 and 7.The serum DAO and D-lactic acid levels were detected to evaluate the gastrointestinal function.Results Demographic and management characteristics of the 3 groups were similar.And there was no difference(P ＞0.05) between asphyxial neonates and normal neonates in clinical manifestation,including type of feeding,delivery mode,etc.A statistical difference (P ＜ 0.05) was found in factors of amniotic fluid turbidity and umbilical cord between asphyxial control group and healthy control group.Compared with asphyxia control study,the content of serum DAO and D-lactic acid on day 1,day 3,day 7 were clearly lower in healthy control group,and the differe-nces were statistically significant(all P ＜ 0.05).The levels of DAO and D-lactic acid in healthy control group were significantly lower than those of asphyxia control group (all P ＜ 0.05).No adverse effect or treating intolerance were noted.Conclusions Mild asphyxia neonatorum impaired the gut barrier function.Compared with placebo,glutamine supplementation can improve the intestinal mucosal barrier function to bettery recovery in asphyxial neonates.