Henoch-Sch（o）nlein purpura with central nervous system dysfunction in 18 children / 中华实用儿科临床杂志

ABSTRACT

Objective To investigate the clinical manifestations,laboratory examinations,treatments and prognosis of Henoch-Schn(o)lein purpura (HSP) children with central nervous system (CNS) dysfunction.Methods All clinical data of HSP patients with CNS dysfunction admitted to Beijing Children's Hospital Affiliated to Capital Medical University,from Jul.2007 to Nov.2012 were reviewed.Their manifestations,laboratory examinations,treatments and prognosis were analyzed.Results There were 18 patients with CNS dysfunctions in all 3512 HSP patients,the major presentations include convulsions,headache,altered level of consciousness and personality changes,et al.Six patients were investigate oligoclonal bands test in cerebrospinal fluid(CSF),4 cases of their results were positive.Thirteen patients did the electroencephalogram (EEG) examination,7 cases were abnormal.Ten patients did the brain CT scan,5 cases of their results were abnormal.Thirteen patients did brain MRI,9 cases were abnormal.After treatment,the CNS manifestations disappeared in all patients.Thirteen patients were follow-up,none of their CNS symptoms relapsed.Conclusions The presentations of patients with CNS system in HSP could be not so typical,and the condition of the patient could be more or less severe,while most of the prognosis of the patients are good.CSF oligoclonal bands test,EEG,brain CT and MRI are beneficial to the diagnosis and evaluation of the HSP associated with CNS dysfunction.