Status-quo and advance of hematopoietic stem cell transplantation in childhood leukemia / 中华实用儿科临床杂志

ABSTRACT

Hematopoietic stem cell transplantation (HSCT) was used in childhood leukemia for over 30 years.In comparison with chemotherapy,the HSCT benefit,in the early,mainly consisted of human leukocyte antigen (HLA) matched sibling donor (MSD) had not been proven,especially in acute lymphocytic leukemia.As improving and applying of HLA typing high-resolution technology,the survival in HSCT from unrelated donor already closed to those from MSD transplant,and the reducing of relapse rate has been seen.Regarding to haploidentical transplant,the result has been improving with advances in methodology,the applying has been expanding,and the long-term following up is going on.Cell therapy has showed exciting outcomes.