Usefulness of Spot Urine beta2-microglobulin in Pediatric Acute Pyelonephritis
Soonchunhyang Medical Science
;
: 91-94, 2012.
Article
in Korean
| WPRIM
| ID: wpr-73337
ABSTRACT
OBJECTIVE:
It is difficult to make a distinction between acute pyelonephritis and lower urinary tract infection due to nonspecific clinical symptoms and laboratory findings. We measured the spot urine beta2-microglobulin in children with urinary tract infection (UTI) to distinguish between acute pyelonephritis and lower UTI. We compared the accuracy of urine beta2-microglobulin measurement with other inflammatory markers.METHODS:
We studied 83 children (mean, 86+/-44.9 months) who suspected of having UTI. Leukocyte counts, erythrocyte sedimentation rates (ESR) and C-reactive protein (CRP), beta2-microglobulin were measured. Renal parenchymal involvement was evaluated by 99mTc dimercaptosuccinic acid scintigraphy in the first 7 days after admission. beta2-microglobulin was measured by radioimmunoassay.RESULTS:
Urine beta2-microglobulin values were correlated with the presence of renal defects in children with UTI (n=22) (0.98+/-0.24 microg/mL, P<0.05). Using a cutoff of 0.4 microg/mL for spot urine beta2-microglobulin and 20 mm/hr for ESR, 2.6 mg/L for CRP, sensitivity and specificity between UTI with and without renal involvement were 78.7% and 90.1% for spot urine beta2-microglobulin, 77.2% and 90.1% for spot urine beta2-microglobulin/creatinine (Cr), 77.2%, 68.8% for ESR, 86.3%, 68.8% for CRP, respectively. Positive and negative predictive values were 72.7%, 90.1% for spot urine beta2-microglobulin, 73.9% and 91.6% for spot urine beta2-microglobulin/Cr, and 57.5%, 94% for CRP, respectively.CONCLUSION:
In febrile UTI, spot urine beta2-microglobulin and beta2-microglobulin/Cr values were more specific than CRP, ESR, and leukocyte count for determine the renal defects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pediatrics
/
Pyelonephritis
/
Urinary Tract Infections
/
Blood Sedimentation
/
C-Reactive Protein
/
Beta 2-Microglobulin
/
Sensitivity and Specificity
/
Technetium Tc 99m Dimercaptosuccinic Acid
/
Leukocyte Count
Type of study:
Diagnostic study
Limits:
Child
/
Humans
Language:
Korean
Journal:
Soonchunhyang Medical Science
Year:
2012
Type:
Article
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