Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs
Toxicological Research
;
: 263-268, 2012.
Article
in English
| WPRIM
| ID: wpr-73343
ABSTRACT
The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu-100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000 mg/kg in Sprague-Dawley rats. An escalating single-dose oral toxicity test in beagle dogs was performed at doses of 500, 1000, and 2000 mg/kg with 4-day intervals. Clinical signs, changes in body weight, mortality, and necropsy findings were examined for 2 weeks following oral administration. No toxicological changes related to the test substance nor mortality was observed after administration of a single oral dose of JKTM-HGu-100 in rats or dogs. Therefore, the approximate lethal dose (LD) for oral administration of JKTMHGu-100 in rats was considered to be over 2,000 mg/kg, and the maximum tolerance doses (MTDs) in rats and dogs were also estimated to be over 2,000 mg/kg. These results indicate that JKTM-HGu-100 shows no toxicity in rodents or non-rodents at doses of 2,000 mg/kg or less.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rodentia
/
Body Weight
/
Administration, Oral
/
Rats, Sprague-Dawley
/
Toxicity Tests
/
Scutellaria
/
Scutellaria baicalensis
Limits:
Animals
Language:
English
Journal:
Toxicological Research
Year:
2012
Type:
Article
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