Expression of Pim-1 in primary hepatocellular carcinoma and its clinical significance / 实用肿瘤学杂志

ABSTRACT

Objective The aim of this study was to determine the expression of Pim-1 in primary hepatocellular carcinoma (PHC)and its clinical significance. Methods Immunohistochemical staining(IHC) was used to detect the expression of Pim-1 in 122 cases of PHC tissues,corresponding paracancer tissues,and 85 normal liver tissues. The relationship between the expression of Pim-1 protein and clinicopathological parameters was analyzed retrospectively. K-M method was used to analyze the effect of differ-ent Pim-1 expression on the survival time of PHC patients. Cox proportional hazard regression models were used to analyze risk fac-tors affecting survival time in patients with PHC. Results The total positive expression rate of Pim-1 protein in PHC tissues was 88. 5% ,which was significantly higher than that in adjacent tissues and normal liver tissues(P<0. 05). Univariate statistical analysis showed that patients with high expression of Pim-1 protein had poor preoperative liver function,more tumors,larger tumor diameter, high incidence of lymph node metastasis and high TNM stage(P<0. 05). Survival analysis suggested that the survival time of patients in the low expression group was significantly longer than that in the high expression of Pim-1 group(P<0. 05). Multivariate statisti-cal analysis showed that high expression of Pim-1 protein was an independent risk factor for survival time in patients with PHC(P<0. 001). Conclusion The expression level of Pim-1 in PHC tissues is significantly increased,which is related to the clinical pro-gress of PHC and the survival time of patients. Pim-1 overexpression indicates the poor prognosis of PHC patients.