Progress in manganese superoxide dismutase in tumor development / 实用肿瘤学杂志

ABSTRACT

Reactive oxygen is closely related to the occurrence and development of tumors. Manganese superoxide dismutase (MnSOD),as an antioxidant enzyme that scavenges superoxide anion in the mitochondrial matrix,plays an important role in maintai-ning mitochondrial redox homeostasis and protecting mitochondrial DNA. Many studies have discovered that MnSOD has different ex-pression levels in different tumors,and has both anti-cancer and cancer-promoting functions,but its functional conversion mecha-nism remains unclear. This article intends to investigate the role of MnSOD in tumorigenesis and development,and to review the main regulatory mechanisms of its expression level and activity.