Therapeutic effect of rehabilitative exercise on angina pectoris and its impact on cardiac autonomic nervous function,IL-6 and BNP level / 心血管康复医学杂志

ABSTRACT

Objective:To study therapeutic effect of rehabilitative exercise on angina pectoris and its impact on cardiac au-tonomic nervous function,levels of interleukin (IL)-6 and brain natriuretic peptide (BNP).Methods:A total of 128 pa- tients with angina pectoris,who were treated in our hospital from Jan 2013 to Dec 2016,were enrolled as rehabilitative ex-ercise group (received routine treatment and rehabilitative exercise ) and treated for six months.Another 128 healthy sub-jects were regarded as healthy control group.Blood lipid levels,indexes of heart rate variability (HRV),levels of IL-6 and BNP were observed and compared between two groups before and after treatment.Results:1.Comparison of blood lipids and BNP (table 2,4)(1) Before vs.after treatment in rehabilitative exercise groupafter six-month treatment,there were significant reductions in levels of TG,TC,LDL-C,IL-6 and BNP,and significant rise in HDL-C level,P＝0.001 all;(2) Comparison between two groups after treatmentCompared with healthy control group after treatment,there were significant rise in levels of TG [ (1.56 ± 0.17) mmol/L vs.(2.15 ± 0.22) mmol/L],TC [ (1.53 ± 0.20) mmol/L vs.(4.01 ± 0.43) mmol/L],LDL-C [ (2.79 ± 0.29) mmol/L vs.(3.21 ± 0.25) mmol/L],IL-6 [ (12.21 ± 1.34) pg/ml vs.(20.18 ± 2.19) pg/ml] and BNP [ (89.96 ± 9.21) ng/L vs.(410.69 ± 42.76) ng/L],and significant reduction in HDL-C level [ (1.16 ± 0.19) mmol/L vs.(0.98 ± 0.11) mmol/L] in rehabilitative exercise group,P＝0.001 all.2.HRV index comparison (table 3)(1) Healthy control group (resting vs.after exercise)after exercise there were signif-icant reductions in lnVLF,lnLF,lnHF and lnTP,and significant rise in ln (LF/HF),P＝0.001 all;(2) Rehabilitative exercise group before treatment (resting vs.after exercise)after exercise only lnVLF significantly reduced,P＝0.005;(3) Healthy control group vs.rehabilitative exercise group before treatment,no matter resting or after exercise,there were significant reductions in lnVLF,lnLF,lnHF and lnTP,and significant rise in ln (LF/HF) in rehabilitative exercise group,P＝0.001 all;(4) Rehabilitative exercise group after treatment (resting vs.after exercise)after exercise there were significant reductions in lnVLF,lnLF,lnHF,lnTP and ln (LF/HF),P＝ 0.001 all;(5) Rehabilitative exercise group resting (before vs.after treatment)after treatment there were significant rise in lnVLF,lnLF,lnHF and lnTP,P＝0.001 all;(6) Rehabilitative exercise group after exercise (before vs.after treatment)after treatment there were sig-nificant rise in lnLF and lnHF,and significant reduction in ln (LF/HF),P＜0.01 all.Conclusion:Rehabilitation exercise can significantly improve blood lipid levels,relieve inflammation,improve cardiac autonomic nervous function with signifi-cant therapeutic effect in patients with angina pectoris,and it＇s safe and reliable.