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Engagement of CD99 Reduces AP-1 Activity by Inducing BATF in the Human Multiple Myeloma Cell Line RPMI8226
Immune Network ; : 260-267, 2015.
Article in English | WPRIM | ID: wpr-73364
ABSTRACT
CD99 signaling is crucial to a diverse range of biological functions including survival and proliferation. CD99 engagement is reported to augment activator protein-1 (AP-1) activity through mitogen-activated protein (MAP) kinase pathways in a T-lymphoblastic lymphoma cell line Jurkat and in breast cancer cell lines. In this study, we report that CD99 differentially regulated AP-1 activity in the human myeloma cell line RPMI8226. CD99 was highly expressed and the CD99 engagement led to activation of the MAP kinases, but suppressed AP-1 activity by inducing the expression of basic leucine zipper transcription factor, ATF-like (BATF), a negative regulator of AP-1 in RPMI8226 cells. By contrast, engagement of CD99 enhanced AP-1 activity and did not change the BATF expression in Jurkat cells. CD99 engagement reduced the proliferation of RPMI8226 cells and expression of cyclin 1 and 3. Overall, these results suggest novel CD99 functions in RPMI8226 cells.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphotransferases / Transcription Factors / Breast Neoplasms / Cell Line / Leucine Zippers / Cyclins / Transcription Factor AP-1 / Jurkat Cells / Lymphoma / Multiple Myeloma Limits: Humans Language: English Journal: Immune Network Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphotransferases / Transcription Factors / Breast Neoplasms / Cell Line / Leucine Zippers / Cyclins / Transcription Factor AP-1 / Jurkat Cells / Lymphoma / Multiple Myeloma Limits: Humans Language: English Journal: Immune Network Year: 2015 Type: Article