The anesthesia effect of propofol combined with small dose of sufentanyl in painless gastroscopy / 中国基层医药

ABSTRACT

Objective To observe the anesthesia effect of propofol combined with small dose of sufentanyl in the painless gastroscopy.Methods From January 2017 to June 2017,68 patients with painless gastroscopy in Lishui Central Hospital were selected in the research.According to the digital table,the patients were randomly divided into observation group (propofol and sufentanil ) and control group (propofol plus fentanyl ),with 34 cases in each group. The anesthesia effect , the intraoperative vital signs , directional recovery and consciousness recovery time were compared between the two groups.The adverse reactions were recorded.Results The effective rate of anesthesia in the observation group was 100.00%,which was significantly higher than 82.35%in the control group (χ2＝8.856, P＜0.05).After medication, the MAP, HR, RR, SpO2in the observation group were ( 73.15 ±6.15 ) mmHg, (67.52 ±9.15)times/min,(11.02 ±2.54)times/min,(91.54 ±1.02)%,respectively,compared with those before medication [(87.51 ±8.16)mmHg,(81.02 ±10.24)times/min,(18.24 ±1.52)times/min,(98.45 ±1.52)%], the differences were statistically significant (t＝8.194,5.732,14.305,5.732,all P＜0.05).After medication,the MAP,HR,RR,SpO2in the control group were (73.20 ±6.16) mmHg, (67.62 ±9.14) times/min, (11.03 ± 2.58)times/min,(91.58 ±1.05)%,respectively,compared with those before medication [(87.59 ±8.14)mmHg, (81.05 ±10.28) times/min,(18.25 ±1.56) times/min,(98.46 ±1.58)%],the differences were statistically significant (t＝8.219,5.692,13.963,21.146,all P＜0.05).The differences of MAP,HR,RR and SpO2between the two groups after medication were not statistically significant (t ＝0.033,0.045,0.019,0.159,all P＞0.05).The orientation force recovery time and consciousness recovery time in the observation group were (3.01 ±0.75) min, (2.02 ±1.05)min,respectively,which were shorter than those in the control group [(4.67 ±1.20)min,(3.71 ± 1.18)min],the differences were statistically significant (t＝6.840,6.238,all P＜0.05).The dosage of propofol of the observation group was (1.03 ±0.19)mg/kg,which was less than (1.77 ±1.58)mg/kg of the control group,the difference was statistically significant (t＝2.711,P＜0.05).The incidence rate of adverse reaction in the observation group (0.00%) was lower than that in the control group (20.59%) (χ2＝7.803,P ＜0.05).Conclusion Application of propofol combined with small dose of sufentanil in painless gastroscopy has satisfactory anesthetic effect,and with stable vital signs,redirected restore and consciousness recovery time ,small adverse reactions,drug safety,it is worthy of clinical promotion.