Analysis of safety and efficacy of live attenuated encephalitis vaccine combined with immunization with live attenuated vaccine against varicella / 中国基层医药

ABSTRACT

Objective To investigate the effect of live attenuated encephalitis vaccine immunization , the effectiveness and safety of live attenuated vaccine against varicella joint vaccination.Methods From January 2015 to December 2016,400 children with vaccination in Yuncheng Municipal Center for Disease Control and Prevention were selected in this research.They were randomly divided into two groups according to the digital table ,with 200 cases in each group.The control group received live attenuated encephalitis vaccine strengthening immunization ,the observa-tion group received live attenuated encephalitis vaccine immunization and live attenuated vaccine against varicella joint vaccination.The positive rate of neutralizing antibody and the incidence of adverse reactions were compared between the two groups.Results The positive rate of encephalitis neutralizing antibody in the observation group was 94.50%,which was significantly higher than 86.00% of the control group (χ2＝8.211,P＜0.05).The incidence rates of adverse reactions in the observation group and the control group were 6.00%,4.50%, respectively, the difference was not statistically significant (χ2＝0.452,P＞0.05).Conclusion The use of live attenuated encephalitis vaccine to enhance immunity and live attenuated varicella vaccine combined inoculation of vaccine can effectively improve the immunity of children to encephalitis virus ,and it is safe and reliable.