Effect of mannatide combined with silver sulfadiazine on the burn wounds / 中国基层医药

ABSTRACT

Objective To observe the effect of mannatide combined with silver sulfadiazine for burn wound. Methods A total of 128 cases with burn wound in the People's Hospital of Yangquan Suburb were selected in the research and randomly divided into two groups according to the digital table ,with 64 cases in each group.The control group was given mannatide treatment ,the observation group was treated with mannatide combined with silver sulfadia-zine.The burn wound appearance ,burn wound healing and the incidence of adverse reactions were compared between the two groups.Results The improve rate of wound,wound exudate rate,decrustation rate in the observation group were 82.81%,18.75%,62.50%,respectively,which were higher than those in the control group (50%,46.88%, 31.25%,χ2＝14.71,11.48,12.55,all P＜0.01).The immediate pain relief rate ,infection rate,incidence rate of scar formation and wound healing time in the observation group were 90.63%,3.13%,12.50%,(16.85 ±1.63)d, respectively,which were significantly better than those in the control group [62.50%,14.06%,28.13%,(23.64 ± 2.16)d],there were statistically significant differences between the two groups (χ2＝14.11,4.87,4.83,t＝20.07, all P＜0.05).The incidence rate of adverse reactions in the observation group was 3.13%,which was significantly lower than 14.06%in the control group (χ2＝4.87,P＜0.05).Conclusion Mannatide combined with silver sulfa-diazine is safe and effective in the treatment of burn wound.It can improve burn wound appearance and shorten wound healing time,which is suitable for use in clinical practice.