Tumor-associated macrophage——New targets for anti-tumor metastasis / 中国医师杂志

ABSTRACT

The interaction between tumor cells and tumor microenvironment is a necessary condition for tumor metastasis.Tumor-associated macrophages (TAM) are macrophages that infiltrate tumor tissues and are the most abundant immune cells in the tumor microenvironment.Tumor-associated macrophages play a key role in tumor invasion and metastasis,and has been suggested an important target for anti-tumor metastasis treatment.This review focuses on the molecular mechanisms related to tumor-associated macrophage polarization and its role in tumor invasion and metastasis.