Advance in application of biomarkers in early diagnosis of lung cancer / 中国综合临床

ABSTRACT

Objective Lung cancer is one of the most common types of malignancy, and the incidence and mortality are the highest among cancers. Increasing the diagnostic rate of early-stage lung cancer is very important to improve the prognosis of patients. The occurrence and development of lung cancer is a complex process mediated by multiple genes and multiple signaling pathways. The detection of biomarkers has received great attention in the early diagnosis of lung cancer. With the deepening of research and advances in detection technology, biomarkers such as autoantibodies, exosomes, circulating tumor cells, circulating tumor DNA, and DNA methylation of lung cancer have been continuously discovered, and precision medicine has been deeply rooted in the hearts of people. This article gives an overview of the research progress of biomarkers in the early diagnosis of lung cancer.