Prognostic value of SIAH2 expression in laryngeal squamous cell carcinoma / 中国肿瘤临床

ABSTRACT

Objective: To investigate the prognostic value of SIAH2 expression in laryngeal squamous cell carcinoma (LSCC). Methods: The qualitative expression of SIAH2 in 119 laryngeal tissues was studied by immunohistochemical staining. Western blot was used to examine the quantitative expression of SIAH2. Survival rates were calculated using the Kaplan-Meier method. Correlation between SIAH2 expression and LSCC patients'prognosis was analyzed by the Log-rank test. The Cox proportional hazards regression model was used to examine the independent predictive factors of LSCC. Results: The SIAH2 expression in LSCC (77.19%) was higher than that in the laryngeal atypical hyperplasia (53.13%) and normal laryngeal tissues (26.67%), and significant differences were observed (χ2=21.02, P=0.000). The expression of SIAH2 was significantly correlated to the histological grade, clinical stage, and lymph node metastasis (P<0.05). The relative expression of SIAH2 in normal laryngeal tissue (1.25±0.04), laryngeal atypical hyperplasia (1.38 ± 0.05), and LSCC (1.44±0.07) was observed to increase gradually (F=61.811, P<0.001). The 5-year survival rate of SIAH2 (+) and SIAH2 (-) patients was 18.18% and 58.33%, respectively (χ2=5.720, P=0.017), and the median survival time of SIAH2 (+) and SIAH2 (-) patients was 25 and 60 months, respectively (P<0.05 ). The multivariate regression analysis revealed that the higher expression of SIAH2 was an independent prognostic factor for the overall survival. Conclusions:SIAH2 may be involved in the tumorigenesis and progression of LSCC as an oncogene. Overexpression of the marker indicated poor prognosis of the disease, a finding which might allow SIAH2 to be used as a potential target gene for the treatment of LSCC.