The dominant immunoglobulin G1 expression in the salivary glands of Sj?gren's syndrome correlates with pathological injury / 中华风湿病学杂志

ABSTRACT

Objective The purpose of this study was to clarify the distribution of immunoglobulin (Ig) G subclasses in the salivary glands of Sj?gren's syndrome (SS). Methods The salivary glands from 70 patients were stained with IgG and IgG subclasses monoclonal antibodies. Clinical data was collected and analyzed between different groups. For group comparisons,measurement data were compared using Student's t test and Mann-Whitney U test, while count data were measured using chi-square test. Results All four IgG subclasses could be detected. IgG could be detected in 36 patients (51％), IgG1 in 32 patients (46％), IgG2 in 3 patients (4％), IgG3 in 5 patients (7％), and IgG4 in 6 patients (9％). IgG1 positive group appeared to have longer duration [(74±75) months (25±36) months, t=3.57, P<0.05), lower white blood cell count (WBC) [(5.5±2.5)×109/L vs (7.3±3.6)×109/L, t=2.38, P<0.05), higher positive rate for antinuclear antibody (ANA), anti-SSA, anti-SSB (97％ and 74％, 93％ and 65％, 47％ and 15％, χ2 was 6.08, 7.46, 8.22 respectively, P<0.05) and more Chisholm 3/4 pathological grade cases (97％与 67％, χ2=9.22), They were all stastically significant (P<0.05). Conclusion IgG1 is the main IgG subclass in the salivary glands of SS. IgG1 may take part in the immunological injury of salivary glands destruction in SS;The dominant IgG1 expression in the salivary glands of SS correlates with pathological injury.