Analysis of serum biochemical indexes in patients with multiple system atrophy / 中华老年医学杂志

ABSTRACT

Objective To study changes in hepatic and renal function,serum lipids and homocysteine levels in patients with multiple system atrophy(MSA),and to explore the relationship of serum biochemical indexes with MSA and its severity.Methods A total of 86 hospitalized patients with MSA at our department from January 2014 to June 2017 were retrospectively analyzed.Eightyfive healthy subjects undergoing health physical examinations at our hospital during the same period were enrolled as a control group.Serum lipid levels and liver and renal function were compared between the two groups.After stratified by gender,the correlations of liver and renal function,serum lipids and homocysteine levels with MSA and its severity were analyzed.Results Serum levels of total cholesterol,high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were lower in the MSA group than in the control group(P＜0.01).Serum levels of total cholesterol,high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were lower in male patients with MSA than in male healthy controls(P＜0.01).Serum levels of uric acid were lower in female patients with MSA than in female healthy controls (P ＜ 0.05).Serum levels of total cholesterol and low-density lipoprotein cholesterol were lower in MSA patients aged under 60 years than in healthy controls aged under 60 years (P ＜ 0.01).Serum levels of total cholesterol (r =0.34,P ＜ 0.01),high-density lipoprotein cholesterol(r =-0.27,P ＜ 0.01),low-density lipoprotein cholesterol(r =0.32,P ＜ 0.01)and uric acid(r =0.15,P ＜ 0.05)were correlated with MSA,but they were not independent risk factors.Serum levels of total cholesterol(r =0.27,P ＜0.05) and low-density lipoprotein cholesterol (r =0.23,P ＜0.05)were correlated with the severity of MSA,but they were not independent risk factors (r =-0.381,P ＞0.05).Conclusions Serum levels of lipids and urea are associated with MSA,but they are not independent risk factors for MSA or its severity.Gender may affect the occurrence of MSA,but it needs to be further confirmed.