Research advances in the mechanisms of silent information regulator 1 in the treatment of myocardial ischemia / 中华老年医学杂志

ABSTRACT

Silent information regulator 1(SIRT1)belongs to nicotinamide adenine dinucleotide(a classic coenzyme) dependent class Ⅲ histone deacetylases.SIRT1 regulates gene expression through altering the acetylation level of nuclear histone and participates in the regulation of a range of important life activities,such as cardiomyocyte autophagy,nucleocytoplasmic shuttling,cell aging,inflammatory responses,etc.It has been showed that SIRT1 plays an important role in myocardial ischemia by mitigating cardiomyocyte apoptosis and enhancing cellular resistance to oxidative stress under ischemic conditions.This article gives an overview of the mechanisms and research progress of SIRT1 in myocardial ischemia,aiming to serve as a reference for myocardial ischemia therapy.