Efficiency and safety of simultaneous resection vs staged resection on in colorectal carcinoma with synchronous liver metastasis:a meta-analysis / 中华普通外科杂志

ABSTRACT

Objective To compare the safety and efficiency between simultaneous resection and staged resection of synchronous colorectal liver metastases.Methods A systematic literature search was performed in PubMed,Embase,Cochrane Library,OVID,Web of Science,WanFang Data,CBM,VIP and CNKI databases for relevant articles published from January 2000 to July,2017.The meta-analysis was performed by RevMan 5.3.The primary outcomes were peri-operative complications,postoperative mortality,five-year survival rate.Results 25 studies with a total of 5 631 patients were finally included.The results of meta-analysis showed that simultaneous and staged resections were similar in peri-operative complications (OR =0.90,P =0.39),postoperative mortality (OR =1.23,P =0.29) and five-year survival rate (OR =1.03,P =0.68).Conclusions Simultaneous resection is safe and efficient in the treatment of patients with SCLMs.However,the results should be interpreted and applied prudently due to the lower level of evidence and the existence of heterogeneity.