The effect of intraoperative administration of S-adenosy-methionine on remnant liver function and regeneration after left lobe resection / 中华普通外科杂志

ABSTRACT

Objective To evaluate the impact of intraoperative administration of S-adenosy-methionine on early remnant liver function and regeneration after left lobe resection.Methods 60 cases undergoing left lobe resection were randomly divided into two groups (30 cases in each group).While postop therapies were the same.Patients in the experimental group received intraoperatively intravenous injection of S-adenosy-methionine 1 000 mg.Postoperatively the two groups were injected with S-adenosy-methionine 1 000 mg/d daily for successive 5 days.Results Liver function injury was markedly alleviated in experimental group after hepatectomy,Level of ALT,AST,TBiL,IBiL index were lower than the control group,the difference was statistically significant (P ＜ 0.05);the LRR and the expression of IL-22 was significantly higher than the control group and the difference was statistically significant (P ＜ 0.05),which indicated improved liver regeneration.Conclusion The intraoperative pretreatment of S-adenosy-methionine can reduce the damage of remnant liver function,promote the restoration of remnant liver function and liver regeneration.