Etiology of second-trimester oligohydramnios: a review / 中华围产医学杂志

ABSTRACT

The second-trimester oligohydramnios can be caused by various factors. Oligohydramnios is associated with adverse pregnancy outcomes. With the development of clinical detection, there was some progress on investigation of the etiology of second-trimester oligohydramnios. Some inheritable diseases associated with oligohydramnios were discovered. Second-trimester oligohydramnios is associated with fetal abnormalities, fetal growth restriction, and fetal, umbilical cord, maternal, or drug factors. Besides them, renal tubular dysgenesis, an autosomal recessive disorder, might be another associated factor of second-trimester oligohydramnios. Birth defects can be avoided by clarifying the etiology of second-trimester oligohydramnios, and the instruction for further pregnancies. Since the etiology of second-trimester oligohydramnios is still unclear, more clinical, pathological and genetic researches are needed.